phar.kindai.ac.jp
Introduction to Chinese Medicine (2nd, 3rd-year)
Practice of Organic Chemistry and Pharmacognosy (2nd-year)
Basic Science for Pharmacy (1st-year)
Staff |
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Professor Hideaki Matsuda
matsudaphar.kindai.ac.jp |
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Natural Drug Resources (1st-year) Introduction to Chinese Medicine (2nd, 3rd-year) Practice of Organic Chemistry and Pharmacognosy (2nd-year) Basic Science for Pharmacy (1st-year) |
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Assistant Chikari Shimakura
chikariphar.kindai.ac.jp |
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Practice of Organic Chemistry and Pharmacognosy (2nd-year) Basic Science for Pharmacy (1st-year) |
１．Development research of anticancer drug from natural drug resources
a. Immunopotentiatory effect
b. Apoptosis inducing effect
c. Antitumor effect
２．Development research of Citrus Fruits
a. Anti-allergy effect
b. Whitening effect
c. Moisturizing effect
3．Development research of hair growth agents and anti-gray hair agents
Search Natural Resources for Novel Medicine
From ancient times, the peoples in the world have continuously endeavored to search environmental natural resources for therapeutic medicines in order to satisfy their desire to be health and longevity. Our laboratories are continuously searching ancient herbal literatures for old wisdom and proving the efficacy of traditional Chinese medicine. On the basis of our fieldwork at Chinese racial minority, Palau, Tonga and Namibia, we are seeking a natural medicine which is not known hitherto in the world in order to discover new drugs for the treatment of refractory diseases, new health-care agents (such as hair-growth agents and whitening agents), new oral-care agents and new materials for supplements. Moreover, we have isolated and identified active constituents of natural resources in which pharmacological activities were found by our experiments.
2006
1. Tokunaga M., Matsuda H., Iwahashi H., Naruto S., Tsuruoka T., Yagi H., Masuko T., Kubo M., Studies on Palauan medicinal herbs. IV. Immunopotentiatory activities of Ongael, leaves of Phaleria cumingii (Meisn.) F. Vill. in diabetic mice. J. Trad. Med., 23, 24-26 (2006).
2. Matsuda H., Hirata N., Kawaguchi Y., Naruto S., Takata T., Oyama M., Iinuma M., Kubo M., Melanogenesis Stimulation in Murine B16 Melanoma Cells by Kava (Piper methysticum ) Rhizome Extract and Kavalactones. Biol. Pharm. Bull. , 29, 834-837 (2006).
3. Matsuda H., Hirata N., Fukuda K., Iwahashi H., Tokunaga M., Iwaki H., Matsuura A., Kubo M., Hypoglycemic Effect of Anti-Diabetic Supplemental Health Foods． Japan. J. Pharmacog. ， 60, 53-58 (2006)．
4. Takaya Y., Shintani T., Tahara E., Tsukioka Y., Moriymama K., Nakao K., Matsuda H., Niizawa A., Ninomiya H., Goto H., Shimada Y., K. Terasawa K., Association of Remnant-like Lipoprotein Particles Cholesterol with “Oketsu” Syndrome. J. Trad. Med. , 23, 147-150 (2006).
5. Niimoto T., Iwahashi H., Nishida N., Ohno T., Matsuura Y., Kawahara Y., Matsuda H., Effect of the Preparation Consisting of three Herbal Extracts on Experimental Fatigue in Rat. Pharmacometrics, 71, 89-93 (2006).
2005
1. Matsuda H., Hirata N., Naruto S., Nishida S., Irimajiri K., Samukawa K., Kubo M., Anti-proliferative Effect of Ginseng Radix on Human Premyelocytic Leukemia Cells (HL-60). J. Trad. Med. , 58, 278-283 (2005).
2. Kubo M., Yamazaki M., Matsuda H., Gato N., Kotani T., Effect of Fruit-juice Concentrate of Japanese Apricot (Prunus mume SEIB. Et ZUCC.) on Improving Blood Fluidity. Natural Medicines，59，22-27 （2005）．
3. Matsuda H., Tokunaga M., Iwahashi H., Naruto S., Yagi H., Masuko T., Kubo M., Studies on Palauan Medicinal Herbs. II. Activation of Mouse Macrophages RAW 264.7 by Ongael, Leaves of Phaleria cumingii (MEISN.) F. VILL. and Its Acylglucosylsterols. Biol. Pharm. Bull. , 28, 929-933 (2005).
4. Matsuda H., Hirata N., Kawaguchi Y., Yamazaki M., Naruto S., Shibano M., Taniguchi M., Baba K., Kubo M., Melanogenesis Stimulation in Murine B16 Melanoma Cells by Umberiferae Plant Extract and Their Coumarin Constituents. Biol. Pharm. Bull. , 28, 1229-1233 (2005).
5. Matsuda H., Tokunaga M., Iwahashi H., Naruto S., Yagi H., Masuko T., Kubo M., Studies on Palauan Medicinal Herbs. III. Antitumor and Immunostimulatory Activities of Ongael, Leaves of Phaleria cumingii (MEISN.) F. VILL. J. Trad. Med. , 58, 278-283 (2005).
6. Matsuda H. (co-author)， Anti-Aging Series No. 1. A New Technology of Restoration for Hair Loss and White Hair. NTS Inc. （2005）．（Book）
2004
1. Matsuda H., Tsukioka Y., Moriyama K., Shintani T., Asano T., Shiomoto H. Kubo M., Studies on Rehmanniae Radix. V. 5-Hydroxymethyl-2-furalaldehyde, Active Constituent of the Steamed Root of Rehmannia glutinosa Having Increasing Activity of Erythrocyte Deformability in Rats. Natural Medicines, 58, 34-37 (2004).
2. Kubo M., Nishimura S., Matsuda H., Nakao K., Tahara E., Shintani T., Study on Anti-allergic Effect of Kampo Medicines Containing Ephedrae Herba on Dinitrofluorobenzene (DNFB)?induced Triphasic Skin Reaction. J. Trad. Med. , 21, 147-153 (2004).
3. Matsuda H., Kawaguchi Y., Yamazaki M., Hirata N., Naruto S., Asanuma Y., Kaihatsu T. Kubo M., Melanogenesis Stimulation in Murine B16 Melanoma Cells by Piper nigrum Leave Extract and its Lignan Constituents. Biol. Pharm. Bull. , 27, 1611-1616 (2004).
4. Matsuda H., Tokunaga M., Hirata N., Iwahashi H., Naruto S., Kubo M., Studies on Palauan Medicinal Herbs. I. Antidiabetic Effect of Ongael, Leaves of Phaleria cumingii (MEISN.) F. Vill. Natural Medicines, 58, 278-283 (2004).
5. Kubo M., Fujita T., Nishimura S., Tokunaga M., Matsuda H., Gato T., Tomohiro N., Sasaki K., Utsunomiya N., Seasonal Variation in Anti-allergic Activity of Citrus Fruits and Flavanone Glycoside Content. Natural Medicines, 58, 284-294 (2004).
6. Nomi T., Shimada T., Motonaga C., Enomoto T., Matsuda H., Kubo M., Prevention from lethal toxicity of 5-Fluorouracil in mice orally treated with Enterococcus faecalis FK-23 preparation．Medical journal of Japanese Red Cross Society Wakayama Medical Center, 22, 85-91 (2004).
7. Kubo M., Matsuda H., Tomohiro N., Harima S., History and Therapeutic Evaluation of Citrus hassaku HORT. Tanaka. YAKUSHIGAKU ZASSHI, 39, 363-364（2004）