phar.kindai.ac.jp
Medicinal Chemistry 1 （3rd Grade）
Medicinal Chemistry 2 （3rd Grade）
Basic Science of Pharmacy （1st Grade）
Practice of Organic Chemistry and Pharmacognocy （2nd Grade）
Practice of Organic and Medicinal Chemistry （3rd Grade）
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Professor Yasuyoshi MIKI y_mikiphar.kindai.ac.jp |
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Practice of Chemistry （1st Grade） Medicinal Chemistry 1 （3rd Grade） Medicinal Chemistry 2 （3rd Grade） Basic Science of Pharmacy （1st Grade） Practice of Organic Chemistry and Pharmacognocy （2nd Grade） Practice of Organic and Medicinal Chemistry （3rd Grade） |
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Lecturer Hiromi HAMAMOTO hamamotophar.kindai.ac.jp |
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Elementary Chemical English （2nd Grade） Basic Science of Pharmacy （1st Grade） Practice of Organic Chemistry and Pharmacognocy （2nd Grade） Practice of Organic and Medicinal Chemistry （3rd Grade） |
1. Synthesis of Indole Derivatives and Their Application for the Creation of Medicinal Drugs
2. Development of New Reaction Methodology in the Filed of Heterogeneous Catalysis
3. Design and Chemical Synthesis of Biologically Active Lead Compounds
The educational program and the research interests of our group include the development of new synthetic method and the synthesis of biologically active natural products. Current topics in our laboratory focus on four major areas. These are (1) indole chemistry, (2) drug design, (3) applied catalysis, and (4) polymer science.
2006
1. Miki Y., Aoki Y., Miyatake H., Minematsu T., Hibino H., Synthesis of caulersin and its isomers by reaction of indole-2,3-dicarboxylic anhydrides with methyl indoleacetates, Tetrahedron Lett., 47, 5215-5218 (2006).
2. Hamamoto H., Kudoh M., Takahashi H., Ikegami S., Novel use of cross-linked poly(N-isopropylacrylamide) gel for organic reactions in aqueous media, Org. Lett., 8, 4015-4018 (2006).
3. Miki Y., Umemoto M., Nakamura M., Hibino H., Kato A., Aoki Y., Bromination of dimethyl indole-2,3-dicarboxylates, Heterocycles, 68, 1893-1899 (2006).
4. Mamedov V. A., Berdnikov E. A., Tsuboi S. Hamamoto H., Komiyama T., Gorbunova E. A. Gubaidullin A. T., Litvinov I. A., Substituted benzaldehydes in the darzens condensation with alkyl dihaloacetates, Russ. Chem. Bull., 55, 1455-1463 (2006).
2005
1. Miki Y., Aoki Y., Tsuzaki Y., Umemoto M., Hibino H., Synthesis of 3-methoxyellipticine and ellipticine by Friedel-Crafts reaction of indole-2,3-dicarboxylic anhydride and selective demethylation, Heterocycles, 65, 2693-2703 (2005).
2. Muto T., Hotta Y., Miyazeki K., Ando H., Ishikawa N., Hasegawa T., Sugimoto Y., Yamada J., Miki Y., Protective effects of sarpogrelate, a 5-HT2A antagonist, against postischemic myocardial dysfunction in guinea-pig hearts Moll Cell. Biochem., 272, 119-132 (2005).
3. Hamamoto H., Suzuki Y., Yamada Y., Tabata H., Takahashi H., Ikegami S.,A recyclable catalytic system based on a temperature-responsive catalyst, Angew. Chem. Int. Ed., 44, 4536-4538 (2005).
4. Hata K., Hamamoto H., Shiozaki Y., Kita Y., A new synthesis of dienonelactones using a combination of hypervalent iodine(III) reagent and heteropoly acid.Chem. Commun., 2465-2467 (2005).
2004
1. Miki Y., Tsuzaki Y., Hibino H., Aoki Y., Synthesis of 3-methoxyolivacine and olivacine by Friedel-Crafts reaction of indole-2,3-dicarboxylic anhydride with 2,4,6-trimethoxypyridine, Synlett, 2206-2208 (2004).
2. Hayashi T., Yasueda S., Nakanishi Y., Ohta H., Kinoshita M., Miki Y., Masuko T., Kakehi K., Capturing of acidic macromolecules from biological samples using a temperature-responsive polymer modified with poly-L-lysine, Analyst, 129, 421-427 (2004).