phar.kindai.ac.jp
Pathophysiology 1 & 2 (3rd grade)
Laboratory Course of Biological Chemistry and Physiology (2nd grade)
Practice of Clinical Pharmacotherapy (4th grade)
Staff |
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Professor@ Atsufumi Kawabata
@kawabataphar.kindai.ac.jp |
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Pathophysiology 1 (2nd grade) Pathophysiology 1 & 2 (3rd grade) Laboratory Course of Biological Chemistry and Physiology (2nd grade) Practice of Clinical Pharmacotherapy (4th grade) |
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Lecturer@ Fumiko Sekiguchi
@fumikophar.kindai.ac.jp |
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Human Physiology 2 (2nd grade) Scientific Reading in English 2 (3rd grade) Laboratory Course of Biological Chemistry and Physiology (2nd grade) Practice of Clinical Pharmacotherapy (4th grade) |
1. Study on proteinase-activated receptors (PARs): physiological/pathophysiological roles for PARs and mechanisms for PAR-mediated intracellular signaling.
2. Study on physiological/pathophysiological roles of hydrogen sulfide (H2S), a novel gaseous messenger.
3. Search for target molecules of H2S in the mammalian body.
4. Study on pain modulation.
One of our research projects is the study on protease-activated receptors (PARs). PARs belong to a novel family of G protein-coupled, seven trans-membrane domain receptors, consisting of four members, PAR1, PAR2, PAR3 and PAR4. We have been investigating the physiological and/or pathophysiological roles for PARs as novel targets for development of drugs. We have reported the roles for PARs in pain modulation, salivary secretion, protection of gastric mucosa, modulation of smooth muscle motility in the gastrointestinal, respiratory and vascular systems, and so on.
Another research project is the study on hydrogen sulfide (H2S). Although H2S is a toxic gas in volcano areas or sewerage disposal plants, H2S is also endogenously generated from L-cysteine by specific enzymes in the mammalian tissues. We have shown that H2S contributes to the modulation of various biological events in the mammalian body, including processing of pain and modulation of vascular tone.
The distinction of our laboratory is to analyze the functions of the specific biological molecules at levels of the gene, protein, cell, tissue and whole body. Therefore, our research covers extensive fields. We have a lot of collaboration with foreign universities, pharmaceutical companies and some laboratories in our own university. The ultimate goal is to contribute to development of new drugs.
2006
1. Kubo, S., Ishiki, T., Doe I., Sekiguchi, F., Nishikawa, H., Kawai, K., Matsui, H., Kawabata, A., Distinct activity of peptide mimetic intracellular ligands (pepducins) for proteinase-activated receptor-1 in multiple cells/tissues. Ann. NY Acad. Sci. (2006), in press.
2. Matsunami, M., Sekiguchi, F., Kawabata, A. Protease-activated receptors. Nippon Yakurigaku Zasshi, 128, 434-436 (2006). (Review in Japanese)
3. Kawabata, A., Proteinase-activated receptors and gastrointestinal function. Nippon Yakurigaku Zasshi, 128, 82-87 (2006). (Review in Japanese)
4. Kawabata, A., Kawao, N., Kitano, T., Matsunami, M., Satoh, R., Ishiki, T., Masuko, T., Kanke, T., Saito, N., Colonic hyperalgesia triggered by proteinase-activated receptor-2 in mice: involvement of endogenous bradykinin. Neurosci. Lett., 402, 167-172 (2006).
5. Kawabata, A., Kawao, N., Hironaka, Y., Ishiki, T., Matsunami, M., Sekiguchi, F., Antiallodynic effect of etidronate, a bisphosphonate, in rats with adjuvant-induced arthritis: involvement of ATP-sensitive K+ channels. Neuropharmacology, 51, 182-190 (2006).
6. Kawabata, A., Matsunami, M., Tsutsumi, M., Ishiki, T., Fukushima, O., Sekiguchi, F., Kawao, N., Minami, T., Kanke, T., Saito, N., Suppression of pancreatitis-related allodynia/hyperalgesia by proteinase-activated receptor-2 in mice. Br. J. Pharmacol., 148, 54-60 (2006).
7. Kawabata, A., Proteinase-activated receptors-2 and pain. Nippon Yakurigaku Zasshi, 127, 133-136 (2006). (Review in Japanese)
8. Sekiguchi, F., Hasegawa, N., Inoshita, K., Yonezawa, D., Inoi, N., Kanke, T., Saito, N., Kawabata, A., Mechanisms for modulation of mouse gastrointestinal motility by proteinase-activated receptor (PAR)-1 and -2 in vitro. Life Sci., 78, 950-957 (2006).
2005
1. Kawao, N., Nagataki, M., Nagasawa, K., Kubo, S., Cushing, K., Wada, T., Sekiguchi, F., Ichida, S., Hollenberg, M.D., MacNaughton, W.K., Nishikawa, H., Kawabata, A., Signal transduction for proteinase-activated receptor-2-triggered prostaglandin E2 formation in human lung epithelial cells. J. Pharmacol. Exp. Ther., 315, 576-589 (2005).
2. Nishikawa, H., Kawabata, A. PAR-2 as a target for gastric mucosal protection. Drugs of Future, 30, 793-798 (2005). (Review)
3. Kawabata, A., Involvement of sensory nerves/TRPV1 in acute pancreatitis. G. I. Research, 13, 387-392 (2005). (Review in Japanese)
4. Nishikawa, H., Kawabata, A. Modulation by PARs of gastrointestinal function. Surgery Frontier, 12, 135-143 (2005). (Review in Japanese)
5. Sekiguchi, F., Development of agonists/antagonists for proteinase-activated receptors (PARs) and the possible therapeutic application to gastrointestinal diseases. Yakugaku Zasshi, 125, 491-498 (2005). (Review in Japanese)
6. Kanke, T., Ishiwata, H., Kabeya, M., Saka, M., Doi, T., Hattori, Y., Kawabata, A., Plevin, R., Binding of a highly potent protease-activated receptor-2 (PAR2) activating peptide, [3H]-2-furoyl-LIGRL-NH2, to human PAR2. Br. J. Pharmacol., 145, 255-263 (2005).
7. Kawabata, A., Oono, Y., Yonezawa, D., Hiramatsu, K., Inoi, N., Sekiguchi, F., Honjo, M., Hirofuchi, M., Kanke, T., Ishiwata, H., 2-furoyl-LIGRL-NH2, a potent agonist for proteinase-activated receptor-2, as a gastric mucosal cytoprotective agent. Br. J. Pharmacol., 144, 212-219 (2005).
8. Kawabata, A., Kawao, N., Physiology and pathophysiology of proteinase-activated receptors (PARs): PARs in the respiratory system: cellular signaling and physiological/pathological roles. J. Pharmacol. Sci., 97, 20-24 (2005). (Review)
9. Kanke, T., Takizawa, T., Kabeya, M., Kawabata, A., Physiology and pathophysiology of proteinase-activated receptors (PARs): Proteinase-activated receptor-2 (PAR-2) as a potential therapeutic target. J. Pharmacol. Sci., 97, 38-42 (2005). (Review)
10. Nishikawa, H., Kawai, K., Tanaka, M., Ohtani, H., Tanaka, S., Kitagawa, C., Nishida, M., Abe, T., Araki, H., Kawabata, A., Protease-activated receptor-2 (PAR-2)-related peptides induce tear secretion in rats: involvement of PAR-2 and non-PAR-2 mechanisms. J. Pharmacol. Exp. Ther., 312, 324-331 (2005).
2004
1. Kimura, T., Arai, M., Masuda, H., Kawabata, A., Impact of a pharmacist-implemented anemia management in outpatients with end-stage renal disease in Japan. Biol. Pharm. Bull., 27, 1831-1833 (2004).
2. Kawabata, A., Nakaya, Y., Ishiki, T., Kubo, S., Kuroda, R., Sekiguchi, F., Kawao, N., Nishikawa, H., Receptor-activating peptides for PAR-1 and PAR-2 relax rat gastric artery via multiple mechanisms. Life Sci., 75, 2689-2702 (2004).
3. Sekiguchi, F., Kawabata, A., Protease-activated receptors (PARs) as therapeutic targets: development of agonists/antagonists and modulation of gastrointestinal functions. Drug Design Reviews, 1, 287-296 (2004). (Review)
4. Kawabata, A., PAR (protease-activated receptor). Seitai No Kagaku 55, 520-521 (2004). (Review in Japanese)
5. Kawabata, A., Kubo, S., Ishiki, T., Kawao, N., Sekiguchi, F., Kuroda, R., Hollenberg, M.D., Kanke, T., Saito, N., Proteinase-activated receptor-2-mediated relaxation in mouse tracheal and bronchial smooth muscle: Signal transduction mechanisms and distinct agonist sensitivity. J. Pharmacol. Exp. Ther., 311, 402-410 (2004).
6. Kawabata, A., Itoh, H., Kawao, N., Kuroda, R., Sekiguchi, F., Masuko, T., Iwata, K., Ogawa, A., Activation of trigeminal nociceptive neurons by parotid PAR-2 activation in rats. NeuroReport, 15, 1617-1621 (2004).
7. Sekiguchi, F., Mita, Y., Kamanaka, Y., Kawao, N., Matsuya, H., Taga, C., Kawabata, A., The potent iNOS inhibitor ONO-1714 inhibits nNOS and exerts antinociception in rats. Neurosci. Lett., 365, 111-115 (2004).
8. Kawabata, A, Kanke, T., Yonezawa, D., Ishiki, T., Saka, M., Kabeya, M., Sekiguchi, F., Kubo, S., Kuroda, R., Iwaki, M., Katsura, K., Plevin, R., Potent and metabolically stable agonists for protease-activated receptor-2: Evaluation of activity in multiple assay systems in vitro and in vivo. J. Pharmacol. Exp. Ther., 309, 1098-1107 (2004).
9. Kawao, N., Ikeda, H., Kitano, T., Kuroda, R., Sekiguchi, F., Kataoka, K., Kamanaka, Y., Kawabata, A., Modulation of capsaicin-evoked visceral pain and referred hyperalgesia by protease-activated receptors 1 and 2. J. Pharmacol. Sci., 94, 277-285 (2004).
10. Kawabata, A., Kubo, S., Nakaya, Y., Ishiki, T., Kuroda, R., Sekiguchi, F., Kawao, N., Nishikawa, H., Distinct roles for protease-activated receptors 1 and 2 in vasomotor modulation in rat superior mesenteric artery. Cardiovasc. Res. 61, 683-692 (2004).
11. Kawabata, A., Nishikawa, H., Saitoh, H., Nakaya, Y., Hiramatsu, K., Kubo, S., Nishida, M., Kawao, N., Kuroda, R., Sekiguchi, F., Kinoshita, M., Kakehi, K., Arizono, N., Yamagishi, H., Kawai, K., A protective role of protease-activated receptor-1 in rat gastric mucosa. Gastroenterology 126, 208-219 (2004).