Pharmaceutical Physical Chemistry

Staff

Professor　 OKABE NOBUO 　okabephar.kindai.ac.jp
	Pharmaceutical Physical Chemistry ( 1st grade) Practices of Pharmacetical Physical Chemistry, Analytical Chemistry and Technology(2nd grade) Life Science (Department of Industrial Administration)

Associate professor　 OKABE NOBUO 　kubokanephar.kindai.ac.jp
	Basic Physical Chemistry(1st grade) Practices of Pharmacetical Physical Chemistry, Analytical Chemistry and Technology(2nd grade) Scientific Reading in English 1(3rd grade)

Research

1. Creation of metal complexes as the pharmaceuticals, and their biophysical studies.
1. 2. Biophysical studies with the interaction between proteins and/or DNA and physiologically Active substances.
3. Development of the electrophoresis method, and characterization of proteins by using the method.

Introduction

Biological functions of biopolymers, proteins and/or DNA are to be enhanced, or damaged by interacting with various substances. In this laboratory, the research object is focused on the physicochemical clarification of the mechanisms of actions of various substances which effect on the structures and functions of biopolymers. As the experimental methods, X-ray analysis, CD, fluorescence and/or electrophoresis methods have been used.

Publication (2004-2006)

2006
1. Odoko, M., Okabe, N. Dichloro(propane-1,3-diamine-κ2N,N')platinum(II), dichloro(propane-1,3-diamine-κ2N,N')palladium(II) and μ-4,9-diazadodecane-1,12-diamine-κ2N1,N4:κ2N9,N12-bis[dichloroplatinum(II)]. Acta Cryst., C62, m136-m139 (2006).
2. Okabe, N., Mizubayashi, Y., Odoko, M. (Benzene-1,2-diolato-κ2O,O')(di-2-pyridylamine-κ2N,N')palladium(II) hemihydrate. Acta Cryst., E62, m2778-m2780 (2006).
3. Okabe, N., Mizubayashi, Y., Odoko, M. (Cyclobutane-1,1-dicarboxylato-κ2O,O')(di-2-pyridylamine-κ2N,N')palladium(II). Acta Cryst., E62, m2747-m2749 (2006).
4. Odoko, M., Nishikawa, N., Okabe, N. cyclo-Tetrakis[4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-olato-κN1:κ2N4,O3]tetrakis[chloropalladium(II)] nonahydrate. Acta Cryst., E62, m2419-m2421 (2006).
5. Yodoshi, M., Odoko, M., Okabe, N. Aqua(di-2-pyridylamine-κ2N2,N2')(D-gluconato-κ2O,O')copper(II) trihydrate. Acta Cryst., E62, m2021-m2023 (2006).
6. Okabe, N., Tomoda, M., Odoko, M. Yodoshi, M. Chloro(N,N'-dimethyldithiocarbamato-κ2S,S')(1,10-phenanthroline-κ2N,N')copper(II). Acta Cryst., E62, m1589-m1591 (2006).
7. Okabe, N., Muranishi, Y., Odoko, M. (Malonato-κ2O,O')(1,10-phenanthroline-κ2N,N')palladium(II). Acta Cryst., E62, m1471-m1473 (2006).
8. Li, L., Wang, Y., Okabe, N., Odoko, M., Lu, T. catena-Poly[[[aqua(di-2-pyridylamine-κ2N,N')nickel(II)]-μ-4-aminobenzoato-κ3O,O':N] chloride trihydrate]. Acta Cryst., E62, m1390-m1392 (2006).
9. Odoko, M., Tsuchida, N., Okabe, N. Aqua{2,2'-[propane-1,3-diylbis(nitrilomethylidyne)]diphenolato}zinc(II). Acta Cryst., E62, m710-m711 (2006).
10. Odoko, M., Tsuchida, N., Okabe, N. Bis{μ-2,2'-[ethane-1,3-diylbis(nitrilomethylidyne)]diphenolato}dizinc(II). Acta Cryst., E62, m708-m709 (2006).
11. Cao, F.-Q., Wang, Y., Okabe, N., Odoko, M. Crystal structure of aquabis(4-aminobenzoato)cadmium dihydrate, Cd(H2O)(NH2C6H4COO)2?2H2O. Z. Kristallogr., 221, 395-397 (2006).

2005
1. Wang, Y., Okabe, N. Synthesis, structures and DNA binding of ternary transition metal complexes M(II)L with the 2,2'-bipyridylamine (L= p-HB, M = Co, Ni, Cu and Zn). Inorg. Chim. Acta, 358(12), 3407-3416 (2005).
2. Odoko, M., Okabe, N. (Adeninato-N9)[N-(2-aminoethyl)salicylideneiminato]palladium(II) 3.5-hydrate. Acta Cryst. SectE., E61(12), m2670-m2673 (2005).
3. Okabe, N., Muranishi, Y. (2,2'-Biquinoline-κ2N,N')dichloroplatinum(II)-2,2'-biquinoline (2/1). Acta Cryst. SectE., E61(11), m2332-m2334 (2005).
4. Yodoshi, M., Odoko, M., Okabe, N. Redetermination of (2,2'-bipyridyl-κ2N,N')chloro(glycinato-κ2N:O)copper(II) dihydrate. Acta Cryst. SectE., E61(11), m2299-m2301 (2005).
5. Wang, Y., Okabe, N., Odoko, M. Crystal structures of palladium(II) ternary complexes of 5-X-2-aminobenzoic acid with 1,10-phenanthroline and their interaction with calf thymus DNA (where X = Cl, Br and I). Chem. Pharm. Bull., 53(10), 1291-1295 (2005).
6. Okabe, N., Aziyama, T., Odoko, M. (1,2-Benzenediolato-κ2O,O')(2,2'-biquinoline-κ2'N,N')palladium(II). Acta Cryst. SectE., E61(10), m2154-m2156 (2005).
7. Okabe, N., Muranishi, Y., Odoko, M. (1,1-Cyclobutanedicarboxylato-κ2O,O')(2,2'-biquinoline-κ2N,N')palladium(II) monohydrate. Acta Cryst. SectE., E61(10), m2060-m2062 (2005).
8. Okabe, N., Muranishi, Y., Mamiko, O. trans-Bis(isoquinoline-3-carboxylato-κ2N,O)bis(methanol-κO)zinc(II). Acta Cryst. SectE., E61(10), m1946-m1947 (2005).
9. Okabe, N., Aziyama, T., Odoko, M. (Benzene-1,2-diolato-κ2O,O')(2,2'-bipyridine-κ2N,N')palladium(II). Acta Cryst. SectE., E61(10), m1943-m1945 (2005).
10. Wang, Y., Okabe, N. Crystal structures and spectroscopic properties of zinc(II) ternary complexes of vitamin L, H' and their isomer m-aminobenzoic acid with bipyridine. Chem. Pharm. Bull., 53(6), 645-652 (2005).
11. Muranishi, Y., Wang, Y., Odoko, M., Okabe, N. (2,2'-Biquinoline-κ2N,N')dichloropalladium(II), -copper(II) and -zinc(II). Acta Cryst. SectC., C61(6), m307-m310 (2005).
12. Wang, Y., Okabe, N. Tetrakis(μ2-1,8-naphthyridine)-1:2κ4N:N';3:4κ4N:N'-bis(μ2-salicylato)-1:4κ2O:O';2:3κ2O:O'-bis (salicylato-κO)bis(salicylic acid-κO)-tetrasilver(I)(4 Ag-Ag). Acta Cryst. SectC., C61(6), m263-m265 (2005).
13. Wang, Y., Okabe, N. X-ray structure characterization of palladium(II) ternary complexes of pyridinedicarboxylic and phthalic acid with phenanthroline and bipyridine. Chem. Pharm. Bull., 53(4), 366-373 (2005).
14. Odoko, M., Okabe, N. μ-Oxo-κ2O:O-bis[bis(1,10-phenanthroline-κ2N,N')(sulfato-κO)iron(III)] octahydrate. Acta Cryst. SectE., E61(3), m587-m589 (2005).
15. Wang, Y., Odoko, M. Mizubayashi, Y., Okabe, N. (Di-2-pyridylamine-κ2N,N')(naphthalene-2,3-diolato-κ2O,O')palladium(II) monohydrate and (di-2-pyridylamine-κ2N,N')(3-oxidonaphthalene-2-carboxylato-κ2O,O')palladium(II). Acta Cryst. SectC., C61(2), m67-m70 (2005).
16. Wang, Y., Okabe, N. Diaquabis(μ-4-hydroxybenzenecarboxylato-κ2O,O')disilver(I)(Ag-Ag) tetrahydrate. Acta Cryst. SectE., E61(2), m382-m384 (2005).
17. Wang, Y., Okabe, N. (2,2'-Bipyridine-κ2N,N')(3-oxidonaphthalene-2-carboxylato-κ2O:O')palladium(II) hemihydrate. Acta Cryst. SectE., E61(1), m3-m5 (2005).

2004
1. Odoko, M., Wang, Y., Okabe, N. (Oxalato-κ2O,O')(1,10-phenanthroline-κ2N,N')palladium(II) monohydrate. Acta Cryst. SectE., E60(12), m1825-m1827 (2004).
2. Wang, Y., Okabe, N. catena-Poly[[(di-2-pyridylamine)silver(I)]-μ-nicotinato] and catena-poly[[(di-2-pyridylamine)silver(I)]-?-2,6-dihydroxybenzoato]. Acta Cryst. SectC., C60(12), m605-m608 (2004).
3. Odoko, M., Okabe, N. Tris(1,10-phenanthroline-κ2N,N')iron(III) trinitrate monohydrate. Acta Cryst. SectE., E60(12), m1822-m1824 (2004).
4. Odoko, M., Wang, Y., Okabe, N. catena-Poly[[(1,10-phenanthroline-κ2N,N')silver(I)]-μ-chloro]. Acta Cryst. SectE., E60(10), m1522-m1524 (2004).
5. Wang, Y., Okabe, N. Di-μ-salicylato-κ4O:O'-bis[(2,2'-bipyridine-κ2N,N')copper(II)] bis(salicylic acid). Acta Cryst. SectE., E60(10), m1434-m1436 (2004).
6. Wang, Y., Odoko, M., Okabe, N. Tetrakis(2,2'-bipyridine-κ2N,N')tetrakis(μ-salicylato-κ3O,O':O'')-quadro-tetrazinc(II) decahydrate. Acta Cryst. SectC., C60(10), m479-m481 (2004).
7. Wang, Y., Odoko, M., Okabe, N. (6-Carboxylatopyridine-2-carboxylic acid-κ2N,O)(pyridine-2,6-dicarboxylic acid-κ2N,O)silver(I) dihydrate. Acta Cryst. SectE., E60(8), m1178-m1180 (2004).
8. Okabe, N., Muranishi, Y., Odoko, M. Cobalt(II), nickel(II) and copper(II) complexes of isoquinoline-3-carboxylate. Acta Cryst. SectC., C60(7), m345-m347 (2004).
9. Kawata, T., Nakamura, S., Nakayama, A., Enomoto, S., Fukuda, H., Ebara, M., Kubo, K., Minami, T., Sakurai, H. Analyses of the metallothioneins and trace metals in the liver and serum of the patients with hepatocellular carcinoma. Biomed. Res Trace Elements, 15(4), 348-350 (2004).
10. Nakamura, S., Kawata, T., Nakayama, A., Kubo, K., Minami, T., Sakurai, H. Implication of the differential roles of metallothionein 1 and 2 isoforms in the liver of rats as determined by polyacrylamide-coated capillary zone electrophoresis. Biochem. Biophys. Res. Commun., 320(4), 1193-1198 (2004).
11. Okabe, N., Hagihara, K., Odoko, M., Muranishi, Y. (2,2'-Bipyridine-κ2N,N')(2,3-naphthalenediolato-κ2O,O')palladium(II) and (2,2'-biquinoline-κ2N,N')(2,3-naphthalenediolato-κ2O,O')palladium(II). Acta Cryst. SectC., C60(4), m150-m152 (2004).
12. Muranishi, Y. Okabe, N. (2,2'-Bipyridine-κ2N,N')(1,1-cyclobutanedicarboxylato-κ2O,O')palladium(II), (1,1-cyclobutanedicarboxylato-κ2O,O')(1,10-phenanthroline-κ2N,N')palladium(II) monohydrate and (1,1-cyclobutanedicarboxylato-κ2O,O')(1,10-phenanthroline-κ2N,N')palladium(II) dihydrate. Acta Cryst. SectC., C60(2), m47-m50 (2004).